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Article

Hypermutagenesis in untreated adult gliomas due to inherited mismatch mutations

11 Dec 2018

Abstract excerpt

Hypermutagenesis refers to marked increase in the number of mutations due to continuous mutagenic process. Hypermutated tumors, have being found in several tumor types, are associated with inherited or acquired alterations in the DNA repair pathways. Hypermutation has been observed in a subset of adult glioma patients as a direct result of temozolomide(TMZ)-induced mutagenesis. In our study, we have identified a...

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PMID: 30536544
DOI: 10.1002/ijc.32054

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