Article
Longitudinal molecular trajectories of diffuse glioma in adults.
Nature - 1 Dec 2019
Barthel Floris P, Johnson Kevin C, Varn Frederick S, Moskalik Anzhela D, Tanner Georgette, Kocakavuk Emre, Anderson Kevin J, Abiola Olajide, Aldape Kenneth, Alfaro Kristin D, Alpar Donat, Amin Samirkumar B, Ashley David M, Bandopadhayay Pratiti, Barnholtz-Sloan Jill S, Beroukhim Rameen, Bock Christoph, Brastianos Priscilla K, Brat Daniel J, Brodbelt Andrew R, Bruns Alexander F, Bulsara Ketan R, Chakrabarty Aruna, Chakravarti Arnab, Chuang Jeffrey H, Claus Elizabeth B, Cochran Elizabeth J, Connelly Jennifer, Costello Joseph F, Finocchiaro Gaetano, Fletcher Michael N, French Pim J, Gan Hui K, Gilbert Mark R, Gould Peter V, Grimmer Matthew R, Iavarone Antonio, Ismail Azzam, Jenkinson Michael D, Khasraw Mustafa, Kim Hoon, Kouwenhoven Mathilde C M, LaViolette Peter S, Li Meihong, Lichter Peter, Ligon Keith L, Lowman Allison K, Malta Tathiane M, Mazor Tali, McDonald Kerrie L, Molinaro Annette M, Nam Do-Hyun, Nayyar Naema, Ng Ho Keung, Ngan Chew Yee, Niclou Simone P, Niers Johanna M, Noushmehr Houtan, Noorbakhsh Javad, Ormond D Ryan, Park Chul-Kee, Poisson Laila M, Rabadan Raul, Radlwimmer Bernhard, Rao Ganesh, Reifenberger Guido, Sa Jason K, Schuster Michael, Shaw Brian L, Short Susan C, Smitt Peter A Sillevis, Sloan Andrew E, Smits Marion, Suzuki Hiromichi, Tabatabai Ghazaleh, Van Meir Erwin G, Watts Colin, Weller Michael, Wesseling Pieter, Westerman Bart A, Widhalm Georg, Woehrer Adelheid, Yung W K Alfred, Zadeh Gelareh, Huse Jason T, De Groot John F, Stead Lucy F, Verhaak Roel G W
Abstract excerpt
The evolutionary processes that drive universal therapeutic resistance in adult patients with diffuse glioma remain unclear1,2. Here we analysed temporally separated DNA-sequencing data and matched clinical annotation from 222 adult patients with glioma. By analysing mutations and copy numbers across the three major subtypes of diffuse glioma, we found that driver genes detected at the initial stage of disease...
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