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Differential Protein Distribution between the Nucleus and Mitochondria: Implications in Aging

16 Sept 2016

Abstract excerpt

The coordination of nuclear and mitochondrial genomes plays a pivotal role in maintenance of mitochondrial biogenesis and functionality during stress and aging. Environmental and cellular inputs signal to nucleus and/or mitochondria to trigger interorganellar compensatory responses. Loss of this tightly orchestrated coordination results in loss of cellular homeostasis and underlies various pathologies and...

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Identifiers

PMID: 27695477
DOI: 10.3389/fgene.2016.00162

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