Article

Global analysis of aging-related protein structural changes uncovers enzyme polymerization-based control of longevity

2023-01-23

Abstract excerpt

Aging is associated with progressive phenotypic changes over time. Virtually all cellular phenotypes are produced by proteins and structural alterations in proteins can lead to age-related diseases. Nonetheless, comprehensive knowledge of proteins undergoing structural-functional changes during cellular aging and their contribution to age-related phenotypes is lacking. Here, we conducted proteome-wide analysis of...

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Literature Corpus work: f5e0dc90-4733-5ef6-9680-e6b919254b69
DOI: 10.1101/2023.01.23.524173

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