Article

Organelle interdependencies underlie the collapse of eukaryotic intracellular organization during cell death and aging

2026-08-28

Abstract excerpt

Complex intracellular organization is a defining feature of eukaryotic cells, and the loss of its integrity is a hallmark of aging and disease. We combined high-content time-lapse imaging and machine learning to quantitatively monitor the morphology of 21 subcellular structures in ~70 million live yeast cells, following conditional inhibition of essential genes. We show that perturbation of essential bioprocesses...

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Literature Corpus work: a3aac92c-95da-5d1d-b5c7-ac227673c08e
DOI: 10.64898/2026.08.25.746993

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