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<i>Ex Vivo</i> Hypothermic Perfusion Enables 48-Hour Heart Preservation and Bench-Top Functional Recovery via Normothermic Reperfusion in a Porcine Model

2025-09-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Ex vivo oxygenated perfusion systems is a promising approach to extend cardiac allograft preservation beyond the typical 4–6h limit allowed by static-cold-storage (SCS). Hypothermic oxygenated perfusion (HOPE) has been proven to safely preserve donor hearts, yet its underlying molecular mechanisms have not been extensively evaluated. <h4>Objectives</h4> The aim of the study...

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Literature Corpus work
1c785223-21ca-5234-8253-100c814206cf
DOI
10.1101/2025.09.03.25335053
Open publication

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