Splice Factor Polypyrimidine tract-binding protein 1 (Ptbp1) is Required for Immune Priming of the Endothelium in Atherogenic Disturbed Flow Conditions

Abstract excerpt

NFκB mediated endothelial activation drives leukocyte recruitment and atherosclerosis, in part through upregulation of adhesion molecules Icam1 and Vcam. The endothelium is “primed” for cytokine activation of NFκB by exposure to low and disturbed blood flow (LDF) in vivo and by LDF or static conditions in cultured cells. While priming leads to an exaggerated expression of Icam1 and Vcam following cytokine stimula...

Topics

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• Arteries
• Atherosclerosis
• Cancer-related molecular mechanisms research
• Cell Adhesion Molecules Research
• Endothelial Cells
• Epigenesis, Genetic
• Gene Expression Regulation
• NF-κB Signaling Pathways

Identifiers and source

Literature Corpus work

fcbe7965-6a3e-5f55-931e-769e984ae70a

DOI

10.1101/2021.06.18.449062