Back to search

Article

The splicing factor kinase SRPK1 is a therapeutic target for Peripheral Vascular Disease

2024-04-22

Abstract excerpt

<h4>Introduction</h4> In peripheral arterial disease (PAD) anti-angiogenic VEGF-A 165 b isoform overexpression in monocytes contributes to impaired collateralisation. Serine-arginine protein-kinase-1 (SRPK1) regulates VEGF splicing. To determine whether SRPK1 controlled monocytic VEGF, impairing collateralisation, we investigated SRPK1 inhibition and monocyte-specific knockout in mouse models of and in human mon...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
fb000948-da86-5f64-8bb7-94df3cb01933
DOI
10.1101/2024.04.17.589996
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The splicing factor kinase SRPK1 is a therapeutic target for Peripheral Vascular DiseaseDOI 10.1101/2024.04.17.589996
Stable Flow-induced Expression of KLK10 Inhibits Endothelial Inflammation and AtherosclerosisSemantic proximity
Splice factor polypyrimidine tract-binding protein 1 (Ptbp1) primes endothelial inflammation in atherogenic disturbed flow conditionsSemantic proximity
Splice Factor Polypyrimidine tract-binding protein 1 (Ptbp1) is Required for Immune Priming of the Endothelium in Atherogenic Disturbed Flow ConditionsSemantic proximity
Inhibiting Anti-angiogenic VEGF165b Activates a Novel miR-17-20a-Calcipressin-3 Pathway that Revascularizes Ischemic Muscle in Peripheral Artery DiseaseSemantic proximity
Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-ASemantic proximity
Vcam1+ Fibro-adipogenic Progenitors Mark Fatty Infiltration in Chronic Limb Threatening IschemiaSemantic proximity
Low dose AKT inhibitor miransertib cures PI3K-related vascular malformations in preclinical models of human diseaseSemantic proximity
Mechano-Initiated PIEZO1-VEGFR2 Interaction Governs CD34 <sup>+</sup> Cell Differentiation and Repair in Arteriovenous FistulaSemantic proximity
Silencing <i>KRIT1</i> Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell TranscriptomeSemantic proximity
Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4).Semantic proximity
Klotho expression in peripheral blood circulating cells is associated with vascular and systemic inflammation in atherosclerotic vascular diseaseSemantic proximity
CTGF is a Modifiable Mediator of Flow-dependent Atherosclerosis under Peripheral Artery Disease ConditionsSemantic proximity
Select a neighboring publication to make it the new centre.