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Article

Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow

2 Jan 2018

Abstract excerpt

Low and disturbed blood flow drives the progression of arterial diseases including atherosclerosis and aneurysms. The endothelial response to flow and its interactions with recruited platelets and leukocytes determine disease progression. Here, we report widespread changes in alternative splicing of pre-mRNA in the flow-activated murine arterial endothelium in vivo. Alternative splicing was suppressed by...

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PMID: 29293084
DOI: 10.7554/elife.29494

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