Article

Endothelial PTBP1 Deletion in Transplanted Cardiac Tissue Limits Cardiac Allograft Vasculopathy

2026-02-19

Abstract excerpt

<h4>Background</h4> Cardiac allograft vasculopathy (CAV) is a leading cause of late graft failure and mortality following heart transplantation, with limited therapeutic options. Endothelial cells (ECs), at the interface between the donor graft and host immune system, play a central role in CAV development. However, the molecular mechanisms driving endothelial dysfunction and vascular remodeling in chronic heart...

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Literature Corpus work: 98b4ac53-499d-59ed-91f3-7c18a01e743a
DOI: 10.64898/2026.02.18.706637

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