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Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes

8 Jul 2024

Abstract excerpt

monocytes contribute to host defense by secreting large amounts of pro-inflammatory cytokines. Their aberrant activity causes hyper-inflammation and life-threatening cytokine storms, while dysfunctional monocytes are associated with 'immunoparalysis', a state of immune hypo responsiveness and reduced pro-inflammatory gene expression, predisposing individuals to opportunistic infections. Understanding how monocyte...

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Share to Inflammasome and immune disorders
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
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PMID: 38977927
DOI: 10.1038/s44321-024-00093-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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