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Article

CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling

1 Aug 2008

Abstract excerpt

The CD40-CD154 dyad seems to play a prominent role fostering the immune-inflammatory response triggered by endothelial cell (EC)-T-cell communication. To delineate comprehensively the involvement of CD40 (TNFRSF5) in EC activation, we combined RNAi-mediated CD40 knockdown with comparative genome-wide transcriptional profiling of ECs interacting with (CD154+) T cells. We report the initiation of a profound stress...

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PMID: 18669876
DOI: 10.1182/blood-2008-03-143305

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