Article

Modeling aging and retinal degeneration with mitochondrial DNA mutation burden

2023-12-01

Abstract excerpt

Somatic mitochondrial DNA (mtDNA) mutation accumulation has been observed in individuals with retinal degenerative disorders. To study the effects of aging and mtDNA mutation accumulation in the retina, a Polymerase gamma (POLG) deficiency model, the POLG D257A mutator mice (PolgD257A), was used. POLG is an enzyme responsible for regulating mtDNA replication and repair. Retinas of young and older mice with this m...

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Literature Corpus work: fcb500fb-6316-5ccb-a8a4-563ad18da7f7
DOI: 10.1101/2023.11.30.569464

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