Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial abnormalities in ageing macular photoreceptors.

Investigative ophthalmology & visual science - 1 Nov 2001

Barron M J, Johnson M A, Andrews R M, Clarke M P, Griffiths P G, Bristow E, He L P, Durham S, Turnbull D M

Abstract excerpt

PURPOSE: To evaluate somatic mitochondrial (mt)DNA mutations in the macula during ageing. METHODS: Ten 30-microm cryostat sections from the macula (foveal and perifoveal regions) and peripheral retina of 14 donors (aged 14-94 years) were cut for cytochrome c oxidase cytochemistry. The photoreceptor layer was microdissected and DNA extracted for 4977-bp mtDNA (mtDNA(4977)) quantification using PCR. Dual...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Cell Count
Share to Cytochrome-c Oxidase Deficiency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Agar Gel

Share to Gene Deletion

Share to Macular Degeneration

Share to Mitochondria

Share to Retinal Cone Photoreceptor Cells

Source

Identifiers

PMID: 11687550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial abnormalities in ageing macular photoreceptors.PMID 11687550Read ↗

Investigating Mitochondria as a Target for Treating Age-Related Macular DegenerationSemantic proximity Read ↗

Mitochondrial DNA Damage as a Potential Mechanism for Age-Related Macular DegenerationSemantic proximity Read ↗

Metabolic dysfunction promoted by mitochondrial DNA mutation burden drives retinal degenerationSemantic proximity Read ↗

Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD)Semantic proximity Read ↗

Mitochondrial Dysfunction in Retinal DiseasesSemantic proximity Read ↗

Mitochondrial DNA damage and repair in RPE associated with aging and age-related macular degeneration.Semantic proximity Read ↗

Mitochondrial alterations of retinal pigment epithelium in age-related macular degenerationSemantic proximity Read ↗

Characterization of retinal and blood mitochondrial DNA from age-related macular degeneration patients.Semantic proximity Read ↗

Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration.Semantic proximity Read ↗

Systemic Evidence for Mitochondrial Dysfunction in Age-Related Macular Degeneration as Revealed by mtDNA Copy Number Measurements in Peripheral BloodSemantic proximity Read ↗

Modeling aging and retinal degeneration with mitochondrial DNA mutation burdenSemantic proximity Read ↗

Mitochondrial DNA haplogroups associated with age-related macular degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.