Article
Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury.
Aging cell - 1 Aug 2011
Kong Yu X G, Van Bergen Nicole, Trounce Ian A, Bui Bang V, Chrysostomou Vicki, Waugh Hayley, Vingrys Algis, Crowston Jonathan G
Abstract excerpt
Mouse models that accumulate high levels of mitochondrial DNA (mtDNA) mutations owing to impairments in mitochondrial polymerase γ (PolG) proofreading function have been shown to develop phenotypes consistent with accelerated aging. As increase in mtDNA mutations and aging are risk factors for neurodegenerative diseases, we sought to determine whether increase in mtDNA mutations renders neurons more vulnerable to...
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