High-quality peptide evidence for annotating non-canonical open reading frames as human proteins

Abstract excerpt

A major scientific drive is to characterize the protein-coding genome as it provides the primary basis for the study of human health. But the fundamental question remains: what has been missed in prior genomic analyses? Over the past decade, the translation of non-canonical open reading frames (ncORFs) has been observed across human cell types and disease states, with major implications for proteomics, genomics, a...

Topics

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• Computational Biology
• Genomics
• Peptidase Inhibition and Analysis
• Polymorphism, Single Nucleotide
• Proteomics
• RNA and protein synthesis mechanisms
• Tandem Mass Spectrometry
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

9ee3c43a-0afd-543e-9824-327c0f1450a5

DOI

10.1101/2024.09.09.612016