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Article

Sex-biasing influence of autism-associated <i>Ube3a</i> gene overdosage at connectomic, behavioral and transcriptomic levels

2022-10-25

Abstract excerpt

Many neurodevelopmental conditions, including autism, affect males more than females. Genomic mechanisms enhancing risk in males may contribute to this sex-bias. The ubiquitin protein ligase E3A gene ( Ube3a ) exerts pleiotropic effects on cellular homeostasis via control of protein turnover and by acting as transcriptional coactivator with steroid hormone receptors. Overdosage of Ube3a via duplication or tripli...

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Literature Corpus work
fca9d710-c5e7-5f00-9186-95bfb5ed3330
DOI
10.1101/2022.10.25.513747
Open publication

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Sex-biasing influence of autism-associated <i>Ube3a</i> gene overdosage at connectomic, behavioral and transcriptomic levelsDOI 10.1101/2022.10.25.513747
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