Article

Shank3 mutation disrupts the molecular signature of sleepiness across development

2026-08-25

Abstract excerpt

<h4>Background: </h4> Sleep problems are common in autism, emerge early in life and reduce quality of life, yet the mechanistic link between autism and poor sleep remains unclear. Human and rodent data indicate that difficulty falling asleep is a core feature of autistic insomnia, pointing to impaired responses to sleepiness as the underlying cause. We previously showed that adult mice carrying a mutation in the h...

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Literature Corpus work: 446680bb-881a-52d4-8bd6-3019817f3920
DOI: 10.64898/2026.08.21.746326

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