Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

USP15 mutation associated with autism spectrum disorder alters progenitor fate and neuronal maturation in human brain organoids.

Molecules and cells - 1 Sept 2026

Park Tae-Hwan, Koh In Gyeong, Sung Seoyoung, Park Hayoon, Kim Jieun, Lee Sebin, Lee Yun Jin, Ko Hyunsoo, Han Jae Hyun, Bong Guiyoung, Yoo Hee Jeong, Kim Jaesang, An Joon-Yong, Lee Ji Yeoun

Abstract excerpt

De novo variants in the ubiquitin-proteasome pathway are linked to autism spectrum disorder (ASD), yet their functional impact on neurodevelopment remains poorly understood. We investigated USP15, a deubiquitinating enzyme with rare damaging variants identified in individuals with ASD, using isogenic human iPSC-derived brain organoids and single-cell transcriptomics. USP15 mutant organoids showed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autism Spectrum Disorder
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Induced Pluripotent Stem Cells

Share to Mutation

Share to Neurons

Share to Organoids

Share to Ubiquitin-Specific Proteases

Source

Open in PubMed Open full text

Identifiers

PMID: 42526765
DOI: 10.1016/j.mocell.2026.100387
PMCID: PMC13499480

Genes

USP15
NR2F1
NR2F2
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

USP15 mutation associated with autism spectrum disorder alters progenitor fate and neuronal maturation in human brain organoids.PMID 42526765Read ↗

Single cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autismSemantic proximity Read ↗

Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genesSemantic proximity Read ↗

ZMYND11 Functions in Bimodal Regulation of Latent Genes and Brain-like Splicing to Safeguard CorticogenesisSemantic proximity Read ↗

Germ-cell-specific transcriptome analysis illuminates the chromatin and ubiquitin pathway in autism spectrum disorders.Semantic proximity Read ↗

Single-cell brain organoid screening identifies developmental defects in autismSemantic proximity Read ↗

USP34 Haploinsufficiency as a Cause of Neurodevelopmental Phenotypes.Semantic proximity Read ↗

Sex-biasing influence of autism-associated <i>Ube3a</i> gene overdosage at connectomic, behavioral and transcriptomic levelsSemantic proximity Read ↗

GABA/Glutamate neuron differentiation imbalance and increased AKT/mTOR signalling in CNTNAP2 <sup>-/-</sup> cerebral organoidsSemantic proximity Read ↗

Biallelic USP14 variants cause a syndromic neurodevelopmental disorder.Semantic proximity Read ↗

FBXW11 Activity Regulates Radial Glial Expansion in Human Cerebral OrganoidsSemantic proximity Read ↗

Schizophrenia-associated <i>NRXN1</i> deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoidsSemantic proximity Read ↗

Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.