Article
Knockdown of Ddx3x in mPFC induces autistic-like phenotype in mice via altered synaptic plasticity.
Translational psychiatry - 30 Mar 2026
Zhuang Hongbin, Cao Xueshan, Tang Xiaoxiao, Liang Zhiyuan, Wang Hanghang, Liu Qiong, Yan Xi, Lin Xixiao, Su Xiaoxi, Wang Mingxian, Huang Yuhan, Lu Dinglin, Wang Yiyuan, Chen Haiyi, Shen Liming
Abstract excerpt
DDX3X, a DEAD-box RNA helicase, has been identified as a risk gene for autism spectrum disorder (ASD). To elucidate the role of DDX3X mutations in ASD pathogenesis, HT22 cell models and mouse models with Ddx3x knockdown specifically in the medial prefrontal cortex were established. Ddx3x knockdown in HT22 cells resulted in slower growth, while in mice, it induced autism-like behaviors. Proteomic analysis in...
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