Expression of Y-Chromosome-Encoded Specific Genes in Mouse and Human Brain Neurons and Their Potential Impact on Sex Differences

Abstract excerpt

<title>Abstract</title> <p>Traditional paradigms hold that Y-chromosome-encoded genes are predominantly expressed in the testes, where they regulate male sexual development and fertility. However, whether these genes are expressed in brain tissue and their functional significance therein have long been overlooked. In this study, we employed C4 single-cell sequencing technology and detected the expression of 11 Y-...

Topics

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• Behavior, Animal
• DEAD-box RNA Helicases
• Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
• Intellectual Disability
• Mutation
• Neurodevelopmental Disorders
• Neurogenesis
• Phenotype

Identifiers and source

Literature Corpus work

4c10f9d0-9b4c-5aa2-bdaf-dd1bc8442224

DOI

10.21203/rs.3.rs-9434261/v1