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Article

Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways

8 Oct 2019

Abstract excerpt

Ubiquitin E3 ligase 3A (UBE3A) encodes an E3 ubiquitin ligase whose loss from the maternal allele causes the neurodevelopmental disorder Angelman syndrome (AS). Previous studies of UBE3A function have not examined full Ube3a deletion in mouse, the complexity of imprinted gene networks in brain nor the molecular basis of systems-level cognitive dysfunctions in AS. We therefore utilized a systems biology approach...

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PMID: 31625566
DOI: 10.1093/hmg/ddz221

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