Article

Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene <i>DDX3X</i>

2024-11-22

Abstract excerpt

<h4>ABSTRACT</h4> DDX3X is an X-linked RNA helicases that escapes X chromosome inactivation and is expressed at higher levels in female brains. Mutations in DDX3X are associated with intellectual disability (ID) and autism spectrum disorder (ASD) and are predominantly identified in females. Using cellular and mouse models, we show that Ddx3x mediates sexual dimorphisms in brain development at a molecular, cellu...

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Literature Corpus work: d755a428-3262-55b5-9451-8f0fb8f5fc14
DOI: 10.1101/2024.11.22.624865

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