Article

Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways

2019-05-24

Abstract excerpt

The genomically imprinted UBE3A gene encodes a E3 ubiquitin ligase whose loss from the maternal allele leads to the neurodevelopmental disorder Angelman syndrome. However, the mechanisms by which loss of maternal UBE3A contribute to severe neurodevelopmental phenotypes are poorly understood. Previous studies of UBE3A function have focused on mouse models or single targets, but these approaches do not accurately r...

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Literature Corpus work: 5435afed-5383-5d93-83c0-fa61331fcf23
DOI: 10.1101/649491

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