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Article

Structural Insights of Fe3+ Induced α-synuclein Fibrillation in Parkinson's Disease.

Journal of molecular biology - 15 Jan 2023

Zhao Qinyue, Tao Youqi, Zhao Kun, Ma Yeyang, Xu Qianhui, Liu Cong, Zhang Shengnan, Li Dan

Abstract excerpt

Amyloid aggregation of α-synuclein (α-syn) in Lewy bodies (LBs) is the pathological hallmark of Parkinson's disease (PD). Iron, especially Fe3+, is accumulated in substantia nigra of PD patients and co-deposited with α-syn in LBs. However, how Fe3+ modulates α-syn fibrillation at molecular level remains unclear. In this study, we found that Fe3+ can promote α-syn fibrillation at low concentration while inhibit...

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PMID: 35690099
DOI: 10.1016/j.jmb.2022.167680

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