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Article

Structural basis behind the interaction of Zn²⁺ with the protein α-synuclein and the Aβ peptide: a comparative analysis.

Journal of inorganic biochemistry - 1 Dec 2012

Valiente-Gabioud Ariel A, Torres-Monserrat Valentina, Molina-Rubino Laura, Binolfi Andres, Griesinger Christian, Fernández Claudio O

Abstract excerpt

α-Synuclein (AS) aggregation is associated to neurodegeneration in Parkinson's disease (PD). At the same time, alterations in metal ion homeostasis may play a pivotal role in the progression of AS amyloid assembly and the onset of PD. Elucidation of the structural basis directing AS-metal interactions and their effect on AS aggregation constitutes a key step towards understanding the role of metal ions in AS...

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PMID: 22832069
DOI: 10.1016/j.jinorgbio.2012.06.011

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IAPP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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