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Article

<i>hapE</i> and <i>hmg1</i> Mutations Are Drivers of <i>cyp51A</i> -Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate

4 May 2023

Abstract excerpt

Triazole resistance is an important cause of treatment failure and high mortality rates for A. fumigatus human infections. Although Cyp51A-associated mutations are frequently identified as the cause of A. fumigatus triazole resistance, they do not explain the resistance phenotypes for several isolates.

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Antifungal resistance and susceptibility
Fungal Infections and Studies
Peptidase Inhibition and Analysis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37140376
DOI: 10.1128/spectrum.05188-22

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<i>hapE</i> and <i>hmg1</i> Mutations Are Drivers of <i>cyp51A</i> -Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical IsolatePMID 37140376Read ↗

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