Article
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.
Nature communications - 21 Aug 2023
Brown Andrew A, Fernandez-Tajes Juan J, Hong Mun-Gwan, Brorsson Caroline A, Koivula Robert W, Davtian David, Dupuis Théo, Sartori Ambra, Michalettou Theodora-Dafni, Forgie Ian M, Adam Jonathan, Allin Kristine H, Caiazzo Robert, Cederberg Henna, De Masi Federico, Elders Petra J M, Giordano Giuseppe N, Haid Mark, Hansen Torben, Hansen Tue H, Hattersley Andrew T, Heggie Alison J, Howald Cédric, Jones Angus G, Kokkola Tarja, Laakso Markku, Mahajan Anubha, Mari Andrea, McDonald Timothy J, McEvoy Donna, Mourby Miranda, Musholt Petra B, Nilsson Birgitte, Pattou Francois, Penet Deborah, Raverdy Violeta, Ridderstråle Martin, Romano Luciana, Rutters Femke, Sharma Sapna, Teare Harriet, 't Hart Leen, Tsirigos Konstantinos D, Vangipurapu Jagadish, Vestergaard Henrik, Brunak Søren, Franks Paul W, Frost Gary, Grallert Harald, Jablonka Bernd, McCarthy Mark I, Pavo Imre, Pedersen Oluf, Ruetten Hartmut, Walker Mark, Adamski Jerzy, Schwenk Jochen M, Pearson Ewan R, Dermitzakis Emmanouil T, Viñuela Ana
Abstract excerpt
We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions. The highest proportion of share genetic regulation is...
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