Article

Distinct chikungunya virus polymerase palm subdomains contribute to virus replication and virion assembly

2024-01-15

Abstract excerpt

Alphaviruses encode an error-prone RNA-dependent RNA polymerase (RdRp), nsP4, required for genome synthesis, yet how the RdRp functions in the complete alphavirus life cycle is not well-defined. Previous work using chikungunya virus (CHIKV) has established the importance of the nsP4 residue cysteine 483 in maintaining viral genetic fidelity. Given the location of residue C483 in the nsP4 palm domain, we hypothesiz...

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Identifiers and source

Literature Corpus work: fc88128e-9b62-562f-895b-2e90f87e81f2
DOI: 10.1101/2024.01.15.575630

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