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Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase

18 Apr 2019

Abstract excerpt

Chikungunya virus (CHIKV) is transmitted to humans through mosquitoes and causes Chikungunya fever. Nonstructural protein 2 (nsP2) exhibits the protease and RNA helicase activities that are required for viral RNA replication and transcription. Unlike for the C-terminal protease, the structure of the N-terminal RNA helicase (nsP2h) has not been determined. Here, we report the crystal structure of the nsP2h bound...

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Identifiers

PMID: 31000599
DOI: 10.1073/pnas.1900656116

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