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Distinct chikungunya virus polymerase palm subdomains contribute to viral protein accumulation and virion production

14 Oct 2024

Abstract excerpt

Alphaviruses encode an error-prone RNA-dependent RNA polymerase (RdRp), nsP4, required for genome synthesis, yet how the RdRp functions in the complete alphavirus life cycle is not well-defined. Previous work using chikungunya virus has established the importance of the nsP4 residue cysteine 483 in replication. Given the location of residue C483 in the nsP4 palm domain, we hypothesized that other residues within...

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PMID: 39401243
DOI: 10.1371/journal.ppat.1011972

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