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Article

Interdomain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity.

Journal of virology - 24 Feb 2021

Law Yee-Song, Wang Sainan, Tan Yaw Bia, Shih Orion, Utt Age, Goh Wei Yang, Lian Bing-Jun, Chen Ming Wei, Jeng U-Ser, Merits Andres, Luo Dahai

Abstract excerpt

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for chikungunya fever. Nonstructural protein 2 (nsP2), a multifunctional protein essential for viral replication, has an N-terminal helicase region (nsP2h), which has both nucleotide triphosphatase and RNA triphosphatase activities, as well as a C-terminal cysteine protease region (nsP2p), which is responsible for nonstructural polyprotein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33328310
DOI: 10.1128/JVI.01470-20
PMCID: PMC8094934

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