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Article

Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription

22 Jan 2019

Abstract excerpt

Chikungunya virus (CHIKV) is a re-emerging Alphavirus causing fever, joint pain, skin rash, arthralgia, and occasionally death.Antiviral therapies and/or effective vaccines are urgently required.CHIKV biology is poorly understood, in particular the functions of the non-structural protein 3 (nsP3).Here we present the results of a mutagenic analysis of the alphavirus unique domain (AUD) of nsP3.Informed by the...

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PMID: 30668592
DOI: 10.1371/journal.ppat.1007239

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