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Article

Structural and functional insights into alphavirus polyprotein processing and pathogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 9 Oct 2012

Shin Gyehwa, Yost Samantha A, Miller Matthew T, Elrod Elizabeth J, Grakoui Arash, Marcotrigiano Joseph

Abstract excerpt

Alphaviruses, a group of positive-sense RNA viruses, are globally distributed arboviruses capable of causing rash, arthritis, encephalitis, and death in humans. The viral replication machinery consists of four nonstructural proteins (nsP1-4) produced as a single polyprotein. Processing of the polyprotein occurs in a highly regulated manner, with cleavage at the P2/3 junction influencing RNA template use during...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23010928
DOI: 10.1073/pnas.1210418109
PMCID: PMC3478664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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