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Structural and phenotypic analysis of Chikungunya virus RNA replication elements

16 Jul 2019

Abstract excerpt

Chikungunya virus (CHIKV) is a re-emerging, pathogenic Alphavirus transmitted to humans by Aedes spp. mosquitoes. We have mapped the RNA structure of the 5' region of the CHIKV genome using selective 2'-hydroxyl acylation analysed by primer extension (SHAPE) to investigate intramolecular base-pairing at single-nucleotide resolution. Taking a structure-led reverse genetic approach, in both infectious virus and...

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PMID: 31350895
DOI: 10.1093/nar/gkz640

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