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Tumor-B-cell Interactions Promote Isotype Switching to an Immunosuppressive IgG4 Antibody Response Through Upregulation of IL-10 in Triple Negative Breast Cancers

2021-12-15

Abstract excerpt

<title>Abstract</title> <p>BackgroundTriple negative breast cancer (TNBC) is an aggressive breast cancer for which there is currently no targeted therapy. Tumor-infiltrating B-cells (TIB) have been observed in tumor tissues of TNBC patients, but their functional role is unclear. IgG4 is one of four antibody subclasses of IgG expressed and secreted by B cells. Unlike other IgG isotypes, IgG4 has an immunosuppressi...

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Literature Corpus work: fc7dacf8-aaca-570d-a43e-1722271b5adf
DOI: 10.21203/rs.3.rs-956230/v2

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