Article

A germline variant of human IgG1+ B cell receptor represses colorectal tumorigenesis and progression by shaping the tumor microenvironment

2021-01-27

Abstract excerpt

<title>Abstract</title> <p>The presence of B lymphocytes in tumor tertiary lymphoid structures (TLSs) is an important prognostic indicator for different types of cancers. However, whether B cell responses in the tumor microenvironment (TME) can be harnessed for immunotherapy is unclear. Here we report that a protective germline variant of human immunoglobulin heavy constant gamma 1 gene (<italic>IGHG1</italic>) c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 97240a28-caf4-588d-a7b2-370e8f96284c
DOI: 10.21203/rs.3.rs-151780/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A germline variant of human IgG1+ B cell receptor represses colorectal tumorigenesis and progression by shaping the tumor microenvironmentDOI 10.21203/rs.3.rs-151780/v1Read

Human colorectal cancer cells frequently express IgG and display unique Ig repertoireSemantic proximity Read

Spatial and phenotypic plasticity of B cells in remodeling the tumor microenvironment.Semantic proximity Read

Immunogenetic Profiling for Gastric Cancers Identifies Sulfated Glycosaminoglycans as Major and Functional B Cell Antigens in Human MalignanciesSemantic proximity Read

IgG4 Characteristics and Functions in Cancer ImmunitySemantic proximity Read

Blocking Immune Checkpoint—LAIR1: Disrupting the LAIR1—FXIII-A—Collagen Immunosuppressive Circuit for Enhanced Antitumor TherapeuticsSemantic proximity Read

Tissue-resident memory B cells augment local anti-cancer immunity via IgASemantic proximity Read

Microbial induction of MHC-II expression in colon cancer cells overcomes immunotherapy resistance and limits metastasisSemantic proximity Read

B cells spatial organization defines their phenotype and function in cancer "Tell me with whom you consort, and I will tell you who you are" - Goethe.Semantic proximity Read

Nanobody-based therapeutics against colorectal cancer: Precision therapies based on the personal mutanome profile and tumor neoantigens.Semantic proximity Read

KLRG1 identifies circulating cytotoxic CD4 T cells with selective anti-tumor function in human cancerSemantic proximity Read

An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms.Semantic proximity Read

Inhibition of host immune response in colorectal cancer: human leukocyte antigen-G and beyond.Semantic proximity Read