Article

Neoadjuvant anti-4-1BB confers protection against spontaneous metastasis through low-affinity intratumor CD8 <sup>+</sup> T cells in triple-negative breast cancer

2025-02-02

Abstract excerpt

<h4>ABSTRACT</h4> Neoadjuvant immunotherapy seeks to harness the primary tumor as a source of relevant tumor antigens to enhance systemic anti-tumor immunity through improved immunological surveillance. Despite having revolutionized the treatment of patients with high-risk early-stage triple-negative breast cancer (TNBC), a significant portion of patients remain unresponsive and succumb to metastatic recurrence p...

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Literature Corpus work: 32d5dd7f-3f94-5f44-b54a-e8c169463bf8
DOI: 10.1101/2025.01.29.635356

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