Article

Structural basis for the folding of PINK1 by the HSP90–CDC37 chaperone complex

2025-10-17

Abstract excerpt

PTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine kinase that plays a central role in Parkin-dependent mitophagy. Mutations in PINK1 are associated with familial Parkinson’s disease. PINK1 is a high-affinity client of the HSP90–CDC37 complex and is stabilized by this chaperone system. However, the molecular mechanism by which HSP90–CDC37 facilitates the folding of PINK1 remains unclear. Here, we pr...

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Literature Corpus work: fc6d2341-f931-595f-8030-b0645b5aa722
DOI: 10.1101/2025.10.17.682828

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