Article

PINK1-G411S mutant increases kinase stability and enhances mitochondrial-linked functions

2024-07-01

Abstract excerpt

<h4>ABSTRACT</h4> PINK1, a mitochondria targeted Serine/Threonine kinase, regulates ATP production by phosphorylating the Complex I subunit NdufA10. However, when in the presence of depolarized mitochondria, PINK1 phosphorylates ubiquitin and Parkin triggering mitochondria clearance. Mutations in PINK1 have been linked to early-onset recessive familial forms of Parkinson’s disease (PD). Deficits in Complex I enzy...

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Literature Corpus work: 715c6dec-284e-5139-b539-dd3f813fc1e0
DOI: 10.1101/2024.06.28.601304

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