Article

Structure of PINK1 reveals autophosphorylation dimer and provides insights into binding to the TOM complex

2021-08-05

Abstract excerpt

<h4>Summary</h4> Mutations in PINK1 causes autosomal-recessive Parkinson’s disease. Mitochondrial damage results in PINK1 import arrest on the Translocase of the Outer Mitochondrial Membrane (TOM) complex, resulting in the activation of its ubiquitin kinase activity by autophosphorylation and initiation of Parkin-dependent mitochondrial clearance. Herein we report crystal structures of the entire cytosolic domain...

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Literature Corpus work: 2f97ea20-5921-591c-848d-71eb9e54eb17
DOI: 10.1101/2021.08.05.455304

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