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Article

PINK1 autophosphorylation is required for ubiquitin recognition.

EMBO reports - 1 Apr 2018

Rasool Shafqat, Soya Naoto, Truong Luc, Croteau Nathalie, Lukacs Gergely L, Trempe Jean-François

Abstract excerpt

Mutations in PINK1 cause autosomal recessive Parkinson's disease (PD), a neurodegenerative movement disorder. PINK1 is a kinase that acts as a sensor of mitochondrial damage and initiates Parkin-mediated clearance of the damaged organelle. PINK1 phosphorylates Ser65 in both ubiquitin and the ubiquitin-like (Ubl) domain of Parkin, which stimulates its E3 ligase activity. Autophosphorylation of PINK1 is required...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29475881
DOI: 10.15252/embr.201744981
PMCID: PMC5891426

Genes

PINK1
RING1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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