Article

MOLECULAR BASIS FOR PINK1 MATURATION

2026-08-23

Abstract excerpt

Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1), a key regulator of mitophagy, has been linked to the pathogenesis of Parkinson's disease (PD). PINK1 recruits Parkin, an E3 ubiquitin ligase, triggering mitophagy in response to mitochondrial damage. During mitophagy, the quantity, stability, and activity of PINK1 must be strictly regulated; however, the mechanisms governing these parameters...

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Literature Corpus work: 2100dbbf-a617-5ac6-babf-22e3f25c5f3a
DOI: 10.64898/2026.08.19.745883

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