Article
L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner.
Neuroscience research - 1 May 2008
Moriwaki Yasuhiro, Kim Yeon-Jeong, Ido Yukari, Misawa Hidemi, Kawashima Koichiro, Endo Shogo, Takahashi Ryosuke
Abstract excerpt
Mutation of PTEN-induced kinase 1 (PINK1), which encodes a putative mitochondrial serine/threonine kinase, leads to PARK6, an autosomal recessive form of familial Parkinson's disease. Although the precise function(s) of PINK1 protein is unknown, the recessive inheritance of this form of Parkinson's disease suggests loss of PINK1 function is closely associated with its pathogenesis. Here we report that PINK1 forms...
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