Article

Deletion of the ncPRC1 Subunit RYBP Located at 3p13 Epigenetically Reprograms Primary Prostate Cancer

2026-02-23

Abstract excerpt

<title>Abstract</title> <p>Polycomb group (PcG) proteins form the Polycomb Repressive Complexes 1 and 2 (PRC1/2), which regulate gene expression through histone modifications. Their dysregulation is implicated in cancer. Genomic analysis of prostate cancer datasets revealed a striking divergence: PRC1 genes are frequently amplified in metastatic disease (SU2C), correlating with poor survival, higher tumor mutatio...

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Literature Corpus work: 3824d5de-0577-5b52-9e5c-f2a770d6e4b0
DOI: 10.21203/rs.3.rs-8711884/v1

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