Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α

20 Aug 2018

Abstract excerpt

BACKGROUND: T helper 17 (Th17) cells have proven to be crucial in the pathogenesis of neutrophils-dominant asthma. Hypoxia inducible factor-1α (HIF-1α) is involved in allergic responses in asthma. Our previous studies indicated that Methtyl-CpG binding domain protein 2 (MBD2) expression was increased in asthma patients. The aim of the present study is to understand how MBD2 interacts with HIF-1α to regulate Th17...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Neonatal Respiratory Health Research
Share to Respiratory Support and Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30150897
DOI: 10.1186/s12950-018-0191-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1αPMID 30150897Read ↗

MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 ExpressionSemantic proximity Read ↗

MBD2 mediates Th17 cell differentiation by regulating MINK1 in Th17-dominant asthmaSemantic proximity Read ↗

Modern View of Neutrophilic Asthma Molecular Mechanisms and Therapy.Semantic proximity Read ↗

MBD2-mediated Th17 differentiation in severe asthma is associated with impaired SOCS3 expressionSemantic proximity Read ↗

Human iPSC-MSCs prevent steroid-resistant neutrophilic airway inflammation via modulating Th17 phenotypesSemantic proximity Read ↗

House dust mite-driven neutrophilic airway inflammation in mice with TNFAIP3-deficient myeloid cells is IL-17-independent.Semantic proximity Read ↗

Emerging roles and therapeutic implications of HDAC2 and IL-17A in steroid-resistant asthmaSemantic proximity Read ↗

The metabolic reprogramming of T cells controls airway remodeling in severe asthmaSemantic proximity Read ↗

Anti-HMGB1 neutralizing antibody ameliorates neutrophilic airway inflammation by suppressing dendritic cell-mediated Th17 polarization.Semantic proximity Read ↗

Th17 profile in COPD exacerbations.Semantic proximity Read ↗

Neutrophilic Asthma and Potentially Related Target Therapies.Semantic proximity Read ↗

FoxO1 regulates allergic asthmatic inflammation through regulating polarization of the macrophage inflammatory phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.