Parkinsonism Reversal and Dopaminergic Resilience: Lessons from a Rotenone-induced Parkinson’s Disease Model

Abstract excerpt

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by profound loss of dopaminergic (DA) neurons, yet the underlying mechanism remains incompletely defined. Mitochondrial toxins can induce acute degeneration of DA neurons and Parkinsonism-like phenotypes in animal models, and epidemiological studies have linked pesticide exposure to increased PD risk; however, the long-term effects...

Topics

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• Antioxidants
• Disease Models, Animal
• Mutation
• Nerve Degeneration
• Neurotoxins
• Parkinson Disease
• Parkinson's Disease Mechanisms and Treatments
• Parkinsonian Disorders

Identifiers and source

Literature Corpus work

1f5ac4d9-8d76-53f5-816a-bcf1197de5a1

DOI

10.64898/2025.12.20.695709