Article

Profiling Human iPSC-Derived Sensory Neurons for Analgesic Drug Screening Using a Multi-Electrode Array

2024-11-19

Abstract excerpt

Chronic pain is a major global health issue, yet effective treatments are limited by poor translation from preclinical studies to humans. To address this, we developed a high-content screening (HCS) platform for analgesic discovery using hiPSC-derived nociceptors. These cells were cultured on multi-well micro-electrode arrays to monitor activity, achieving nearly 100% active electrodes by week two, maintaining sta...

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Literature Corpus work: fc0a2624-2ba7-5858-b215-f05c3acae511
DOI: 10.1101/2024.11.18.623405

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