Article

A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells

2025-05-04

Abstract excerpt

Human cellular models of disease developed using induced pluripotent stem cells (iPSC) have enabled wide-ranging research from investigation of human disease mechanisms to phenotypic drug screens. Pain disorders such as neuropathic pain and headache remain areas of considerable unmet need and are considered high risk by pharma. Human iPSC-derived sensory neurons have already been used to accelerate translational r...

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Literature Corpus work: bb02f889-30d0-5258-b865-34a1c0286ca4
DOI: 10.1101/2025.04.29.651263

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