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Plate-Based Phenotypic Screening for Pain Using Human iPSC-Derived Sensory Neurons.

SLAS discovery : advancing life sciences R & D - 1 Jul 2018

Stacey Peter, Wassermann Anne Mai, Kammonen Laura, Impey Emma, Wilbrey Anna, Cawkill Darren

Abstract excerpt

Screening against a disease-relevant phenotype to identify compounds that change the outcome of biological pathways, rather than just the activity of specific targets, offers an alternative approach to find modulators of disease characteristics. However, in pain research, use of in vitro phenotypic screens has been impeded by the challenge of sourcing relevant neuronal cell types in sufficient quantity and...

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PMID: 29547351
DOI: 10.1177/2472555218764678

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